Human Sera
Cayman Chemical Chlorfenapyr 100mg
A pyrrole pro-insecticide; metabolized in vivo into CL 303268; increases respiratory activity in vivo in German cockroaches at 1-10 UG/insect but not in vitro in Sf9 insect cells at 1-100 µM or isolated rat liver mitochondria; active against insects susceptible and resistant to pyrethroid and organophosphate insecticides, including mosquitoes that carry malaria (LC50s = 2-2.39% suspension impregnated on paper); lethal to rats (LD50s = 441 and 1,152 mg/kg for male and female rats, respectively)
Cayman Chemical ResorufInsodIum salt 100mg
A fluorescent probe; has been used in the synthesis of resorufin-based fluorescence probes; has also been used for the direct measurement of solvent-solute hydrogen bond dynamics with distinct absorption and emission peaks in solvents with strong hydrogen bonds and overlapping peaks in solvents with weak hydrogen bonds; ex/em = 570/580 nm, respectively
Cayman Chemical TesaglItazar 50mg
A dual agonist of PPARα and γ (IC50s = 1 and 0.2 µM, respectively) that at 3 µM/kg/day for 3 weeks has been used to reduce insulin resistance in obese Zucker rats
Cayman Chemical RactopamInhydrochlorIde 100mg
A TAAR1 agonist; increases chloride conductance in X. laevis oocytes expressing human CFTR and mouse TAAR1 (EC50 = 16 µM); selectively induces chloride conductance in TAAR1- and CFTR-expressing oocytes over those expressing the human β2-ARs at 36 µM; considered a β2-AR agonist that binds to recombinant human β2-ARs in Sf9 cells and induces relaxation of isolated guinea pig trachea (EC50 = 9.1 nM)
Cayman Chemical 1MethylhIstamInhydroCLOr 100mg
A major metabolite of histamine used as a biomarker of histaminergic system activity via CSF levels in Alzheimer’s disease patients
Cayman Chemical UmbelIferon 50mg
A derivative and metabolite of coumarin with diverse biological activities; inhibits growth of human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells at 250-300 UG/ml; increases ROS production and halts the cell cycle in KB human oral carcinoma cells; has antidepressant-like activity in a rat model of depression induced by chronic unpredictable mild stress at 15 and 30 mg/kg; used as a ratiometric pH indicator with ex/em = 330 and 370/460 nm at low and high pH, respectively
Cayman Chemical AmbenonIumchlorIde 50mg
An AChE inhibitor (IC50 = 0.7 nM); selective for AChE over BChE (IC50 = 6.82 µM); increases the secretion of APP in primary rat basal forebrain cells at 10 µM; induces repetitive firing of electrically stimulated gastrocnemius muscle in anesthetized cats at 5 UG/animal; inhibits tubocurarine- or decamethonium-induced paralysis in anesthetized cats at 3 UG/animal
Cayman Chemical AmIprofos-methyl 100mg
An herbicide; reversibly decreases H. vulgare root and shoot length and inhibits in vitro paclitaxel-induced tubulin polymerization in a dose-dependent manner; completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM; inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM; inhibits the growth of P. falciparum (IC50 = 3.5 μM); completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM
Cayman Chemical AlflutInIbmesylate 50mg
An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg
Cayman Chemical DebrIsoquInhemIsulfate 50mg
A post-ganglionic sympathetic blocker; increases accumulation of l-m-octopamine in isolated rabbit heart at 1 mM; reduces norepinephrine levels in the left and right atrium and ventricles, as well as the mesenteric and femoral arteries in anesthetized dogs at 5 mg/kg per day for 7 days; decreases mean aortic pressure, heart rate, and total peripheral vascular resistance in the same model.
Cayman Chemical TrImethadIon 50mg
An anticonvulsant; decreases the levels of α-oxoglutarate, malate, and fumarate in the brain, as well as plasma glucose levels in rats; increases latency to first pentetrazole-induced clonic seizure in mice (ED50 = 10 mg/kg); inhibits absence-like seizures but not tonic convulsions in spontaneously epileptic rats
Cayman Chemical PhentolamInmesylate 100mg
A reversible antagonist of α-adrenergic receptors, non-specifically binding all α1- and α2-adrenoceptors with nanomolar affinities; rapidly and transiently increases local blood flow
Cayman Chemical 1S 3R3AmInocyclopentn c 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical TebIpenmhydrate 100mg
A carbenapenem antibiotic; active against a panel of clinical isolates from a variety of bacterial species (MIC50s = ≤0.0039-8 UG/ml); inhibits β-lactamase; decreases the number of CFUs in the lungs in a mouse model of penicillin-resistant S. pneumoniae infection at doses ranging from 0.32 to 3.2 mg/kg